WebNumb specifically regulates NPC1L1-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2, which selectively participate in LDLR … WebAnti-NUMB (C-terminal) antibody produced in rabbit is polyclonal, unconjugated and is suitable for western blot. Products. NL EN. Products. Applications Products Services Support. All Photos (1) N6539. Anti-NUMB (C-terminal) antibody produced in rabbit ~1.0 mg/mL, affinity isolated antibody. All Photos (1) Synonym(s): Anti-S171. NACRES:
Anti-NUMB Antibodies Invitrogen - Thermo Fisher Scientific
WebNumb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. WebNumber of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue section. "Estimation of protein expression could not be performed. View primary data." bmw japan style
Two novel human NUMB isoforms provide a potential link …
Web2 feb. 2024 · Deregulated alternative splicing of the endocytic adaptor NUMB resulting in high expression of Exon9in (exon 9-containing) isoforms has been reported in several cancer types. However, the role of Numb isoform expression in tumor progression and the underlying mechanisms remain elusive. Web27 jun. 2024 · To test further whether a suitable NUMB isoform switch and MEC differentiation maintenance are linked, we stably introduced NUMB short cDNA (siRNA-resistant) or an empty vector into CD44 low MECs. Using a NUMB siRNA targeting its native 3′UTR, the endogenous NUMB long isoform was efficiently depleted while NUMB short … Web19 okt. 2024 · Using conditional mouse genetics and tauopathy disease models, we report here that Numb is an essential regulator of intraneuronal Tau levels and prevents degeneration of tauopathy neurons in an isoform-specific manner. RESULTS Numb is required for long-term neuronal survival bmw jaipur