Biological role of anti-aging protein klotho
Web2012). The systemic effects of Klotho protein appear to be primarily due to its circulating form of secreted soluble Klotho protein, which operates as a humoral factor (Chang et al. 2005) – potentially through bind-ing to its putative, yet still unknown, cell-surface receptor – and as an enzyme regulating the biological WebFeb 19, 2024 · Klotho (KL), named after the Greek goddess of destiny who was the spinner of the thread of life, is involved in the aging process and may act as an anti-aging hormone in mammals. The KL gene is located in chromosome 13 in humans. It encodes a transmembrane protein with an extracellular domain, a transmembrane domain, and an …
Biological role of anti-aging protein klotho
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WebJun 15, 2024 · Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. In 1997, an accidental insertion … WebIntroduction. Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span resembling human premature aging after this gene was serendipitously silenced. 1 The klotho-deficient phenotype can be rescued by overexpressing klotho via genetic …
WebFeb 3, 2024 · Background: Klotho is an anti-aging protein with sever al therapeutic role s in the pathophysiology of dif ferent or gans, such as the skele tal muscle and kidneys. WebApr 9, 2024 · Klotho is an anti-ageing protein that can attenuate ageing-related diseases to extend healthspan. 8, 9 α-Klotho declines with ageing in mice and humans. 10 …
WebThe absence of this protein in knockout mice causes their accelerated aging. 8 Most works describing the functions of Klotho investigate the role of this protein in mechanisms of suppressing various age-related pathologies of the ... Kong ID, Cha SK. Biological role of anti-aging protein Klotho. J Lifestyle Med. 2015;5(1):1. doi:10.15280/jlm ... WebDec 1, 2024 · For instance, Klotho is able to downregulate inflammatory cytokines and attenuate the generation of reactive oxygen species, acting as an anti-inflammatory protein (Kim et al., 2015). Although accelerated aging profile has been described in BD and the chronic low-grade inflammation is a feature of both BD and aging, the biology linking BD …
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WebDec 9, 2024 · Biological Role of Anti-Aging Protein Klotho. Klotho is an anti-aging protein that is mostly detected in the kidney and brain. It was first identified in mice as … chunking worksheets readingWebKlotho is an aging suppressor protein that is abundant in kidney tissue and Klotho-knockout mice have been shown to develop a syndrome similar to premature aging (30,31). The present study focused on determining the relevance of radiation-induced cellular senescence and the involvement of Klotho. chunking words examplesWebSleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation. However, there are no studies elucidating the relationship between sleep and Klotho. Therefore, this study investigated the association of sleep quantity … chunking words worksheet pdfWebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney … chunking year 3WebKlotho plays a major role in kidney disease as much of the Klotho protein circulating in the blood is produced in the kidneys. ... Aging is a complex biological process regulated by multiple intrinsic and extrinsic factors such as genetics, epigenetics, environment, lifestyle, and immune response. Aging is often defined as an age-related ... chunking words listWebDec 1, 2024 · Klotho, an anti-aging protein (soluble or membrane-bound) plays a prominent role in understanding the aging process. It exerts various protective activities for neurons and multiple organs. Klotho ... chunking words worksheetWebMar 17, 2024 · Klotho, an anti-aging protein expressed in the distal convoluted tubules ... Biological variability and analytical issues account at least partly for this inconsistency. ... Cheng, C.Y.; Kuro-o, M. Role of Klotho in aging, phosphate metabolism, and CKD. Am. J. Kidney Dis. 2011, 58, 127–134. [Google Scholar] ... chunking words reading strategy